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There are a number of ways that SGS AXYS targeted analysis of specific analytes can aid with the study of these diseases, body systems and practice areas. Here are just a few highlights below:
Obesity is a disorder that affects the entire body and involves various metabolic changes. AXYS has a number of panels that readily detect subtle changes in the metabolic system to increase the insights into obesity and obesity-related diseases.
Targeted metabolomic approaches using MS/MS are able to help rationalize the clinical diagnosis of inborn errors of metabolism (IEM): a rare group of genetic disorders that can have serious clinical consequences for neonates, children, and adults. Left undiagnosed and untreated, IEM can cause physical disability, irreversible mental retardation, and neurological damage. Targeted metabolomics has recently been gaining popularity in newborn screening of dried blood spots for IEM and is proving to be a cost-effective approach to facilitate rapid diagnosis, earlier treatment intervention and better patient outcome. Metabolites of interest provided by AXYS via newborn screening of dried blood spots:
Cardiovascular disease (CVD) is globally the primary public health concern for both men and women and the leading cause of death. Targeted metabolomic profiling approaches hold great promise in identifying independent, incremental biomarkers and mechanisms for CVD risk.
Alzheimer’s disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, and eventually even the ability to carry out the simplest tasks. As many as 5 million Americans age 65 and older may have Alzheimer’s disease. Targeted metabolomics of blood and CSF has shown to be a powerful tool for the diagnosis and exploration of critically-needed biomarkers for AD:
Many studies have demonstrated that autoimmune disease (AD) patients can be distinguished from healthy individuals using metabolic profiling accompanied with well-established data analysis tools such as principal component analysis (PCA). Glucose, amino acid and lipid metabolism, as well as neurotransmitters, nucleotides, immune responses and anti-inflammatory responses are affected by AD. Knowledge of unique metabolomic fingerprints in AD are useful for both diagnosis and treatment of disease.
Targeted metabolomics is an important tool in the diagnosis and monitoring of metabolic diseases such as amino acids defects (phenylketonuria, maple syrup urine disease, tyrosinemia I, argininemia, homocystinuria, carbamoyl phosphate synthetase deficiency, ornithine transcarbamylase deficiency, nonketotic hyperglycinemia), organic acidurias (methylmalonic aciduria, propionic aciduria, glutaric aciduria I, 3-hydroxy-3-methylglutaric aciduria, isovaleric aciduria), and mitochondrial defects (medium-chain acyl-coenzyme A dehydrogenase deficiency, carnitine palmitoyltransferase II deficiency). Some of the panels that AXYS can provide to aid with Metabolic diseases:
Aging is an irreversible and progressive process that includes the accumulation of cellular and organ damage, leading to a decline in function. As a result, metabolic dysfunction is a common hallmark of the aging process and aging-related pathogenesis. The discovery of aging and aging-related disease biomarkers is important for the early diagnosis and therapy of pathologies. The utility of targeted metabolomics for the discovery and validation of disease biomarkers has been recently established and is proving to be an effective tool in this field of study.
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