Phthalates, or dialkyl or alkyl aryl esters of 1,2-benzenedicarboxylic acid, are a family of compounds used in a variety of applications such as plasticizers in polyvinyl chloride, and additives in lubricant, paints, pesticides, and personal care products. With studies suggesting toxicity in animals, high potential of human exposure from consumer products, and widespread presence in the general population in the US, the use of phthalates and their metabolites is facing increasing scrutiny from the scientific community and regulators as a potential public health issue. Although phthalates are metabolized and excreted quickly they are suspected to have estrogenic activity.
AXYS performs GC-MS analysis of phthalate esters (phthalates) in sediment, soil, sludge, tissue and water. Samples are typically spiked with a suite of deuterium labeled surrogate standards and extracted. Eight phthalates are reported by this method and concentrations are reported in ng/g or ng/L.
Phthalate ester metabolites are also analyzed by AXYS — We provide low-level measurement of mono phthalate esters and their conjugates in aqueous samples by LC-MS/MS instrumentation for use in specialized research such as Body Burden studies. AXYS has analyzed mono phthalate esters and metabolites in urine since 2006. Typical reporting limits are in the ng/mL range.
Method Description Phthalates (phthalate esters) by GC-MS Analysis of 8 phthalate esters by MLA-027 Phthalate ester metabolites in urine by LC-MS/MS Analysis of 10 phthalate ester metabolites and BPA in aqueous/urine samples by MLA-059
AXYS Supports SFU Study for Biomonitoring
Since 2008, AXYS has been providing Phthalate metabolite analysis of paired infant and maternal urine in support of the longitudinal CHILD program conducted through Simon Fraser University and partners including Health Canada. More than 5000 samples were analyzed for SFU over an eight year period from 4 collection sites (Vancouver, Edmonton, Winnipeg, and Toronto), then analyzed over a 3 month period at AXYS.