Bisphenol A (BPA) is receiving increasing scrutiny from regulators and the scientific community world-wide as a contaminant of concern due to its estrogenic potential. BPA is a chemical produced in large quantities for use in the production of polycarbonate plastics and epoxy resins, which can be found in many products such as food and drink packaging and medical devices. Many studies have shown BPA to be estrogenic, developmentally toxic, and to act as a precursor to breast cancer. Globally, over six-billion pounds of BPA are used each year.
Exposure to bisphenol A is from a variety of routes. These include oral pathways (products placed into the mouth), ingestion of household dust or skin contact. The ester bonds in these BPA-based polymers are subject to hydrolysis, allowing small amounts of the BPA to leach out of the products. Although rapidly metabolized and excreted from the body, adverse effects of BPA have been observed at levels less than the current EPA threshold level. In the environment, recent studies have demonstrated biodegradation of BPA in surface water and sediments and efficient removal by activated sludge wastewater treatment systems in wastewater treatment systems. The current focus for bisphenol A and its metabolites is occurrence and its endocrine disrupting effects within humans.
BPA in human serum and urine
In 2005, AXYS led the industry in offering analysis of bisphenol A and its glucuronide metabolites in human serum and urine by LC-MS/MS instrumentation. Required measurements are usually in the nanogram or lower range. We are at the forefront of analytical laboratories offering this complex test and have analyzed hundreds of samples in a variety of biomonitoring programs.
BPA in aqueous and environmental samples
Since 2008, AXYS has also been analyzing BPA in water and environmental samples such as sediment. AXYS specializes in measurement of BPA to nanogram or lower concentrations from standard sample sizes. Our specialized sampling and analytical procedures may allow for much lower detection limits, as well as allow for reduced sample sizes for difficult samples such as human and sediment matrices. We deliver legally defensible data under IEC/ISO 17025 certified systems applying methods accredited by NELAP and CALA. Electronic Data Deliverables (EDD), customized for download to our clients relational databases, are available in addition to standard format report and full data packages.
BPA in Wastewater Plants
AXYS has analyzed more than 200 WWTP effluents, septage, biosolid amended soils and solids from septage fields for BPA from the Ontario Ministry of the Environment. Projects have included reconnaissance and ongoing studies to determine levels of POPs in the environment from different industries and processes.
AXYS Experienced with Biosolids and Water for BPA Analysis
Since 2010, AXYS has been analyzing influent, effluent, and biosolid samples for the Environment Canada Aquatic Ecosystems Management Research Division, to determine the occurrence and solids/water partitioning of BPA and other compounds in WWTP processes. The program requires the collection in triplicate (3 consecutive days) for biosolids and influents / effluents at each stage of treatment in each WWTP facility. The process is repeated twice, once in warm weather months and once in cold weather months.